Martin Nurmik

A postdoctoral researcher in life sciences focusing on molecular biology, oncology, and the tumour microenvironment. Areas of interest are three-dimensional tumour modelling, cancer-associated fibroblasts, stroma-driven cytokine interactions, and multicellular cross-talk.

Mammalian cell culture (human, mouse), Bacterial and yeast cell culture (E.coli, S.cerevisiae), Primary cell culture establishment (epithelial, stromal), 2D invasion & co-culture assays (transwell invasion assays, tumor-on-chip), 3D invasion and co-culture assays (organotypic hydrogel assays, multicellular tumor spheroid culture), Organoid establishment and culture, T-cell proliferation assays, Cellular stemness assays (sphere formation assays), Multi-color flow cytometry, Fluorescence-activated cell sorting, ELISA, RNAseq, qRT-PCR, SDS-PAGE, Western Blot, Cell viability assays (MTT, CellTiter-Glo), Cytokine Arrays (Cytokine XL profiler), Automated imaging microscopy (Cytation 5), Agarose gel electrophoresis, Mass spectrometry, molecular cloning, siRNA, shRNA, Lentiviral transduction, miRNA analysis, Gene set enrichment analysis (Ingenuity Pathway Analysis), Immunohistochemistry, Fluorescence microscopy, MACS cell separation, Rheometric assays, Fluorescence in situ hybridization (FISH) 

BD FACSCanto II, LSRFortessa, FACSAria III, MACSQuant 10, Clariostar, Cytation 5, Incucyte, Qubit, Nanodrop 2000, Agilent 2100 Bioanalyzer, gentleMACS Octo Dissociator, Cedex XS Analyser, CFX96/384 Real Time System, Histocore Biocut, CASY Cell Counter, EVOS XL, Fusion FX, Biometra Trio, Axiovert 40 CFL 

Koncina E*, Nurmik M*, Pozdeev VI*, et al. IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer. Nature Communications. 2023;14(1). doi:10.1038/s41467-023-39953-w

*These authors contributed equally

Nurmik, M., Ullmann, P., Rodriguez, F., Haan, S., & Letellier, E. (2019). In search of definitions: Cancer‐associated fibroblasts and their markers. International Journal of Cancer, 146(4), 895–905. https://doi.org/10.1002/ijc.32193

Ullmann P, Nurmik M, Schmitz M, et al. Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity. Cancer Letters. 2019;450:32-41. doi:10.1016/j.canlet.2019.02.030

Ullmann P, Nurmik M, Begaj R, Haan S, Letellier E. Hypoxia- and MicroRNA-Induced metabolic reprogramming of Tumor-Initiating cells. Cells. 2019;8(6):528. doi:10.3390/cells8060528

Xu, K., Liang, Z., Ding, X., Hu, H., Liu, S., Nurmik, M., Bi, S., Hu, F., Ji, Z., Ren, J., Yang, S., Yang, Y., & Li, L. (2017). Nanomaterials in the Prevention, Diagnosis, and Treatment of Mycobacterium Tuberculosis Infections. Advanced Healthcare Materials, 7(1), 1700509. https://doi.org/10.1002/adhm.201700509

Qureshi-Baig, K., Kuhn, D., Viry, E., Pozdeev, V. I., Schmitz, M., Rodriguez, F., Ullmann, P., Koncina, E., Nurmik, M., Frasquilho, S., Nazarov, P. V., Zuegel, N., Boulmont, M., Karapetyan, Y., Antunes, L., Val, D., Mittelbronn, M., Janji, B., Haan, S., & Letellier, E. (2019). Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway. Autophagy, 16(8), 1436–1452. https://doi.org/10.1080/15548627.2019.1687213

Tennis, Debate, Chess, Literature